BACKGROUND: To inform future decision-making on pandemic preparedness for COVID-19, we evaluated the acceptability and perceived feasibility of implementation strategies for COVID-19 self-testing among decision-makers in Mozambique. National and provincial directors, heads of programs and division chiefs were selected as decision-makers.

METHODS: We conducted semi-structured interviews with decision-makers involved in COVID-19 diagnosis, management, and policy development. Topics included knowledge and perceptions of COVID-19, testing policies, implementation considerations, and linkage to care. Using a thematic approach, we analysed the interviews.

RESULTS: Seventeen decision-makers were interviewed—most perceived self-testing as an acceptable strategy for early COVID-19 detection. The benefits were improved access to testing, decongesting health facilities, minimising infection risk and decreasing healthcare workers’ workload. Concerns included low testing interest in the post-pandemic period, literacy barriers, affordability and equity issues, mistrust that patients might not take the test due to fear of positive results, and the healthcare system’s capacity to follow up positive cases.

CONCLUSION: COVID-19 self-testing is feasible and acceptable to decision-makers; however, the changing epidemiology has shifted perspectives. This study highlights self-testing’s value in emergencies and pandemic preparedness, enabling rapid detection and isolation of cases, thus minimizing the spread of infectious diseases in vulnerable populations in Mozambique and similar contexts.

KEYWORDS: policy, pandemic response, surveillance.